暴露于金属加工液体和非酒精性脂肪肝疾病之间的关系
Weiling Chan1, Geyang Li1, Li Zhou1
1Division of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226001, Jiangsu, China.
International archives of occupational and environmental health
|December 9, 2023
概括
职业接触金属加工液 (MWF) 是非酒精性脂肪肝疾病 (NAFLD) 的危险因素. 增加MWF暴露与NAFLD的更高患病率相关,每日6.54毫克/立方米的门被确定.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 肝病学 肝病学是一种肝病学.
- 环境医学 环境医学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 职业金属加工流体 (MWF) 暴露与NAFLD之间的联系以前没有被调查过.
- 了解这种关系对于工人健康和安全至关重要.
研究的目的:
- 调查职业MWF暴露与NAFLD患病率之间的关联.
- 为了确定与NAFLD风险相关的MWF的每日暴露值.
主要方法:
- 对一家机械加工厂的2079名员工进行了问卷调查和职业健康检查.
- 使用NIOSH 5524方法收集和分析了MWF样本.
- NAFLD的诊断是基于肝肥胖症指数 (HSI) ≥36,不包括显著的酒精消费. 后勤回归被用于分析.
主要成果:
- 职业MWF暴露被确定为NAFLD的一个显著风险因素 (OR=1.42,95% CI:1.04-1.95).
- 观察到剂量-反应关系,MWF暴露增加与NAFLD风险更高相关.
- 与NAFLD风险增加相关的MWF的每日暴露值被确定为6.54 mg/m3 (OR=2.09,95% CI:1.24-3.52).
结论:
- 职业接触MWF与NAFLD的患病率增加有关.
- 高度的MWF暴露与增加的NAFLD风险相关.
- 确定暴露门对于减轻MWF暴露的工人的NAFLD至关重要.
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