在体外和体外,蒂奥里达的抗莱什曼活动
Sergio Sifontes-Rodríguez1, Niurka Mollineda-Diogo2, Lianet Monzote-Fidalgo3
1División de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Acta parasitologica
|December 9, 2023
概括
作为一种抗精神病药物的 thioridazine 在体外和体内表现出显著的抗莱什马尼亚寄生虫的抗莱什马尼亚活性. 这一发现支持将蒂奥里达重新作为莱什曼病的潜在治疗方法.
科学领域:
- 寄生虫学的寄生虫学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 莱什曼病是一种被忽视的热带疾病,由于药物成本,毒性和耐药性,治疗选择有限.
- 药物重定向提供了一种有效的策略,用于识别像莱什曼病这样被忽视的疾病的新疗法.
研究的目的:
- 评估现有的抗精神病药物 thioridazine 的抗莱什曼病活性.
- 评估蒂奥里达对各种莱什马尼亚物种的疗效,以及其作为重用药物的潜力.
主要方法:
- 蒂奥里达的细胞毒性在小鼠腹巨细胞上进行了测试.
- 在实验室中对Leishmania amazonensis,Leishmania mexicana和Leishmania主要前列腺炎和细胞内前列腺炎进行了评估.
- 在皮肤莱什曼病的小鼠模型中评估了疗效.
主要成果:
- 蒂奥里达在体外显示出强大的活性,对抗被测试的Leishmania物种的前列腺菌 (IC50:0.733.8μM) 和细胞内巨乳菌 (IC50:1.274.4μM).
- 该药物对巨细胞具有较低的细胞毒性 (CC50: 24.0 ± 1.89 μM),表明有利的治疗窗口.
- 在体内, thioridazine显著抑制了病变的发展,并减少了皮肤leishmaniasis的小鼠模型中的寄生虫负载.
结论:
- 蒂奥里达对Leishmania寄生虫的多个阶段和物种有效.
- 抗精神病药物 thioridazine 显示出作为抗莱什曼病治疗剂的重新利用的希望.
关键词:
莱什曼亚亚马逊人种 (Leishmania amazonensis) 是一个亚马逊人种.莱什曼尼亚大型 (Leishmania major) 是一个很大的病.墨西哥的莱什曼尼亚.莱什曼病是一种莱什曼病.提奥里达辛 (Thioridazine) 是一种类型的氨基酸.更多相关视频
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