在早产的成年人中增加白质纤维分散和较低的智商分数
Winok Lapidaire1,2, Jonathan D Clayden1, Mary S Fewtrell1
1UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Human brain mapping
|December 9, 2023
概括
过早出生的成年人显示白质纤维分散增加和IQ得分降低. 先进的扩散MRI指标,如方向分散,可以跟踪这些终身大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 放射学 放射学是一门学科.
背景情况:
- 早产与白质变化和认知缺陷有关.
- 传统的扩散张力成像 (DTI) 模型难以区分髓化与纤维方向变化.
- 先进的扩散MRI模型提供了研究白质微观结构的新方法.
研究的目的:
- 为了研究早产成人的高级扩散MRI指标 (显微异性异性,方向分散) 的变化.
- 评估这些微观结构变化与认知表现之间的关联.
- 探索高级扩散MRI在监测早产儿的实用性.
主要方法:
- 招募了72名早产儿和72名早产儿的成年人.
- 获得的多扩散MRI数据.
- 使用球形平均技术 (SMT) 计算了张量FA,微观FA和方向分散 (ODE).
- 用于全尺度智商 (FSIQ),口头理解指数 (VCI) 和感知推理指数 (PRI) 的简化智商测试 (WASI-II).
- 使用基于通道的空间统计 (TBSS) 来进行音量比较.
主要成果:
- 过早生育的成年人表现出明显较低的FSIQ,VCI和PRI得分.
- 在早产个体中观察到ODE的广泛下降,表明纤维分散增加.
- 两组之间没有发现微观FA的显著差异.
- 张量FA显示,在早产的个体中,前面的冠状辐射量略有增加.
- 在早产成年人中,较低的张量FA值与较低的FSIQ和PRI得分相关.
结论:
- 过早出生的成年人表现出白质纤维分散增加和认知能力下降.
- 先进的扩散MRI指标,特别是ODE,对早产儿一生中的白质变化敏感.
- 这些发现强调了高级扩散MRI在早产后长期监测大脑发育的潜力.
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