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Updated: Jul 9, 2025

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Published on: July 5, 2018

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人体IgA和J链上的每个N-甘氨酸都独特地影响了寡合性和稳定性

Shunli Pan1, Noriyoshi Manabe1, Shiho Ohno1

  • 1Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Miyagi, Japan.

Biochimica et biophysica acta. General subjects
|December 9, 2023
PubMed
概括

免疫球蛋白A1 (IgA1) 上的N-甘氨酸对其结构至关重要. 在IgA1-Fc上的N459-甘氨酸对于形成二次体和防止聚合物至关重要,而其他甘氨酸则稳定复合物.

关键词:
在Fc Fc Fc免疫球蛋白A (IgA) 是一种这是一个J链.通过N链接的糖基化.蛋白质组合组件的组合蛋白质的稳定性 蛋白质的稳定性

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