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Updated: Jul 9, 2025

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建立基于融合网格的CYP2C18模板系统,并将其应用于药物代谢

Yasushi Yamazoe1, Kouichi Yoshinari2

  • 1Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, 980-8578, Japan; Division of Risk Assessment, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki, 210-9501, Japan.

Drug metabolism and pharmacokinetics
|December 9, 2023
PubMed
概括

研究人员开发了一个新的系统来预测小酶细胞P450 2C18 (CYP2C18) 如何代谢化学物质. 这有助于推进药物安全性和疗效评估,提供了以前研究不足的CYP酶的数据.

关键词:
在CYP2C18中介的代谢中.合并网格模板 合并网格模板抑制的模式 抑制的模式差的和好的基板.在模板上模拟连接体相互作用.

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