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目标TLR4抑制剂的设计,合成和抗风湿性关节炎活性

Wenbin Wang1, Shiyang Zhou2, Wenming Jiang1

  • 1Chongqing Chemical Industry Vocational College, Chongqing 401228, China; Chongqing (Changshou) Green Chemical and Material Industry Technology Research Institute, Chongqing 401228, China.

Bioorganic & medicinal chemistry
|December 9, 2023
PubMed
概括

针对托尔类受体4 (TLR4) 的新药候选药物在类风湿关节炎治疗中表现有前途. 化合物3p在临床前模型中有效抑制细胞增殖和关键炎症标志物,表现优于甲状腺素.

关键词:
在 RAW264.7 中,单元是 RAW264.7 .类风湿性关节炎 类风湿性关节炎 类风湿性关节炎这是一种TLR4抑制剂.

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