年龄对体重指数和发生中风亚型风险之间的关系的影响:JPHC研究
Hanson Gabriel Nuamah1, Yuanying Li1, Hiroshi Yatsuya1
1Department of Public Health and Health Systems, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
概括
身体质量指数 (BMI) 和中风风险根据亚型表现出不同的关联,与缺血性中风有线联系,与脑内出血有曲线联系,无论年龄组如何.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 心血管疾病研究研究
背景情况:
- 据报道,身体质量指数 (BMI) 和中风亚型,特别是脑内出血之间存在不一致的关联.
- 以前的研究可能受到BMI测量年龄的影响,导致发现的变化.
研究的目的:
- 研究年龄对BMI与不同类型中风亚型风险之间的关系的影响.
- 澄清BMI和中风之间的关联,考虑到随年龄的潜在变化.
主要方法:
- 一项前性队列研究在日本跟踪了88,754名年龄在40-69岁之间的参与者.
- 身体质量指数 (BMI) 是自我报告和分类. 使用了依赖时间的考克斯比例危险模型,分析按年龄组 (40-59岁和≥60岁) 分层.
主要成果:
- 在两年龄组BMI和缺血性中风风险之间观察到正线性关联 (p < 0.001).
- 在中年和老年参与者 (p=0.017和p=0.098,分别) 中,BMI和脑内出血风险之间发现了曲线联系.
- 无论是中风亚型,BMI和年龄组之间的相互作用都没有统计学意义.
结论:
- 体重指数和整体中风风险之间的关联在各年龄组之间没有显著差异.
- 然而,BMI和中风亚型 (如缺血性中风和脑内出血) 之间的具体关系可能有所不同.
- 这些发现强调了在检查BMI相关风险时考虑中风亚型的重要性.
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