在患有慢性鼻炎的患者中,有或没有同时出现喘的患者中,有氧过敏原敏感化模式
Tássia Milenna Oliveira de Souza1, Jamille Souza Fernandes2, Cinthia Vila Nova Santana3
1Universidade Federal da Bahia, Salvador, BA, Brazil.
Brazilian journal of otorhinolaryngology
|December 9, 2023
概括
与单独患有慢性鼻炎 (CR) 和喘的患者相比,慢性鼻炎 (CR) 和喘患者的过敏原敏感率更高. 然而,过敏原敏感化模式与CR患者的喘严重程度没有显著差异.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 慢性鼻炎 (CR) 经常与喘并发.
- 了解CR患有喘和没有喘患者的过敏原敏感化模式,对于有效管理至关重要.
- 喘的严重程度可能会受到过敏原敏感化的类型和程度的影响.
研究的目的:
- 调查慢性鼻炎 (CR) 患有喘或不患喘的个体中空气过敏原敏感化模式的差异.
- 分析喘严重程度如何与CR患者的特定过敏原敏感化概况相关.
- 为了确定在CR的背景下,亚托皮是否是喘严重程度的主要驱动因素.
主要方法:
- 评估了1066名成年人,使用专家诊断,问卷和喘和CR的皮肤刺伤测试.
- 现型特征包括皮肤刺伤测试,用于扩展的空气过敏原面板,总IgE和肺功能.
- 参与者被分为单独CR (CRA),轻度喘CR (CRMA) 和中度至重度喘CR (CRMSA).
主要成果:
- 与CRA (47.0%) 相比,患有喘的CR患者 (CRMA 70.4%,CRMSA 65.0%) 的aeroallergen敏感性显著更高.
- 喘与多种空气过敏原敏感性 (51.5%) 和对虫,,动物毛皮,草和菌的更高敏感性有关.
- 像Alternaria alternata,Cladosporium herbarum和狗等特定的过敏原在喘组中显示出独特的敏感性.
结论:
- 慢性肺炎患者的喘与多种过敏原敏感性有关.
- 在患有喘的CR患者中存在独特的空气过敏原敏感性概况.
- 关于喘严重程度,没有观察到敏感度的显著差异,这表明在这个人群中,喘严重程度的主要机制不是阿托皮.
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