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由VIP内部神经元的消抑制与初级视觉皮层中的交叉模式注意力调制是正交的

Dylan Myers-Joseph¹, Katharina A Wilmes², Marian Fernandez-Otero¹

¹Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.

|December 9, 2023

概括

注意调制和血管活性肠 (VIP) 内神经元消毒抑制使用不同的神经通路. 这些独特的机制允许在相同的神经群体内进行多重,非相互作用的认知控制.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
计算神经科学是一种神经科学.

背景情况:

感官处理的注意调节对于认知至关重要,但它的神经基础仍然不清楚.
血管活性肠 (VIP) 和体静止素 (SOM) 阳性内部神经元是金字塔细胞消抑制的候选媒介.
注意力和VIP-SOM消抑制之间的相互作用尚未经过实验研究.

研究的目的:

为了研究注意力调节和VIP内部神经元介导的消抑制之间的相互作用.
阐明了注意力和消抑制的基础的神经电路机制.
为了确定注意力和VIP-SOM消抑制是否涉及重叠或不同的神经回路元素.

主要方法:

利用全光学方法对小鼠的VIP内部神经元活动进行双向操纵.
采用跨模式的注意力转换任务来评估认知表现.
测量了同一组织内VIP,SOM,帕瓦胺 (PV) 阳性内神经元和金字塔细胞中的神经元活动.

主要成果:

所有测量细胞类 (VIP,SOM,PV,Pyramidal) 的神经元活动都通过注意力和VIP操纵来调节.
发现注意力和VIP操纵对神经活动的影响是正交的.
注意力和VIP-SOM消抑制涉及抑制细胞和激发细胞之间不同的活动变化模式和网络重组.

结论:

注意力和VIP-SOM消抑制在相同的神经群体中代表着不同的,非相互作用的调制机制.
电路建模支持能够复杂化这些独立调制的网络架构.
研究结果提供了关于认知灵活性和感官处理的神经基础的见解.

关键词:

一个VIP的VIP的VIP的关注注意力注意力注意力注意力内部神经元内部神经元帕尔瓦尔胺是什么?索马托斯塔丁是什么? 索马托斯塔丁是什么视觉皮层视觉皮层视觉皮层

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