用于临床研究的儿童和青少年支气管切除症的一个核心结局:国际共识研究研究
Anne B Chang1, Jeanette Boyd2, Andrew Bush3
1Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD, Australia; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia; NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
针对儿科非囊性纤维化支气管病的核心结果集 (COS) 的开发确保了一致的,以患者为中心的研究. 这种标准化的方法将改善患有这种疾病的儿童的临床护理和治疗结果.
科学领域:
- 儿科肺病学 儿科肺病学
- 临床研究方法论 临床研究方法论
- 患者报告的结果
背景情况:
- 儿童非囊性纤维化支气管切除症需要标准化的研究结果.
- 现有的研究缺乏对儿科患者和护理人员有意义的健康结果的共识.
- 患者和家长的观点对于制定相关研究目标至关重要.
研究的目的:
- 建立一个国际的,多学科的核心结果集 (COS) 儿科非囊性纤维化支气管病.
- 将患者和家长的观点纳入开发重要研究成果.
- 促进一致的,以患者为中心的研究和基于证据的指导方针.
主要方法:
- 系统性审查以确定潜在的结果.
- 为家长,患者和医疗保健专业人员开发调查.
- 国际共识会议最终确定了核心成果.
主要成果:
- 开发了一个由十项组成的核心成果集 (COS).
- 确定了五个基本结果:生活质量,症状,恶化频率,非计划的医疗保健访问和住院治疗.
- 来自17个国家 (家长/患者) 和58个国家 (医疗保健专业人员) 的562名参与者做出了贡献.
结论:
- 基于共识的COS确保在儿科支气管病症研究中获得一致的,以患者为中心的结果.
- 该COS的实施将促进全球研究和改进的临床指导方针的开发.
- 需要进一步的研究来开发可验证的COS结果测量仪器.
更多相关视频
07:46Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung
Published on: June 5, 2012
09:26Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
相关概念视频
COPD: Management Using Bronchodilators and Corticosteroids
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
