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Updated: Jul 9, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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在恶性黑色素瘤中,BRD9状态是通过MST和EAAT3调节对氨酸代谢重塑的主要贡献者

Ana Hipólito1, Renato Xavier2, Cheila Brito2

  • 1iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal; Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto, 1099-023 Lisboa, Portugal.

Biochimica et biophysica acta. Molecular basis of disease
|December 9, 2023
PubMed
概括

BRD9基因突变改变了氨酸的新陈代谢,增加了黑色素瘤细胞的生长和传播. 这一发现揭示了遗传性黑色素瘤,并为这种侵袭性皮肤癌提供了新的治疗点.

关键词:
这就是BRD9的原因.皮肤黑色素瘤是一种皮肤黑色素瘤.半氨酸的代谢过程代谢重塑是指新陈代谢的重塑.

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