相关实验视频
Updated: Jul 9, 2025

07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
19.4K
在向加拿大急救部门提出的儿童中,牛奶诱导的过敏反应
Sam Amar1, Rose Di Ioia1, Sofianne Gabrielli1
1Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
概括
医院前使用上腺素治疗儿科牛奶过敏是低的,但可能会减少重复的紧急用上腺素. 年幼的孩子可能会有较轻的反应,喘息和吐更为常见.
科学领域:
- 儿科过敏和免疫学
- 过敏反应管理 过敏管理
- 食物过敏的流行病学 食物过敏的流行病学
背景情况:
- 牛奶过敏是一种常见的儿科过敏原,可能导致严重的过敏反应.
- 关于小儿牛奶诱导的过敏反应的数据有限.
- 过敏反应需要迅速识别和管理.
研究的目的:
- 调查小儿牛奶诱导的过敏反应的流行病学.
- 为了确定重复的急诊室 (ED) 上腺素管理的风险因素.
- 评估医院前治疗对过敏反应严重性的影响.
主要方法:
- 在加拿大10个ED中对3118个过敏反应进行了回顾性分析 (2011年4月至2023年5月).
- 确定了319例牛奶诱导的过敏反应病例.
- 使用多变量逻辑回归来确定重复ED上腺素使用的风险因素.
主要成果:
- 牛奶诱导的过敏反应占病例的10%.
- 在54%的牛奶诱导的过敏反应病例中,医院预先给出了上腺素.
- 医院前上腺素与减少重复ED上腺素的需求有关 (aOR 0.95).
- 5岁以下的儿童有较轻的反应;较大的儿童有中度反应.
- 与其他食物过敏反应相比,牛奶诱导的过敏反应病例呈现出更多的喘息和吐,以及较少的血管.
结论:
- 在儿童牛奶诱导的过敏反应中不充分使用医院前上腺素需要解决.
- 早期使用上腺素可能会减少ED中重复剂量的需要.
- 牛奶诱导的过敏反应可能因年龄而异,较小的孩子会经历不那么严重的反应.
相关概念视频
Allergic Reactions
27.4K
Overview
27.4K
Hypersensitivities
673
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
673
Allergic Drug Reactions
846
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
846
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
305
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
305
Antibody Structure
60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K
Adrenergic Agonists: Therapeutic Uses
787
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
787

