胸部和腹部肌肉的发育取决于SDF1和CXCR4
Imadeldin Yahya1, Aisha Abduelmula2, Dorit Hockman3
1Department of Anatomy and Molecular Embryology, Ruhr University Bochum, Bochum, Germany; Department of Anatomy, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan.
Developmental biology
|December 9, 2023
概括
这项研究表明,CXCR4/SDF-1信号通路对于脊椎动物侧侧体壁肌肉发育至关重要. 这一途径调节肌肉祖先的迁移,影响整体肌肉形成.
科学领域:
- 发展生物学 发展生物学
- 分子生物学分子生物学
- 脊椎动物的胚胎发生
背景情况:
- 在脊椎动物中,侧侧体壁肌肉的形成传统上与皮肤肌瘤的生长有关.
- 然而,腰带,四肢和舌头的肌肉来自远程迁移的祖先,这个过程取决于CXCR4信号传递.
研究的目的:
- 为了研究CXCR4信号在体壁肌肉发育过程中皮肤的腹侧唇 (VLL) 中的作用.
- 阐明背后的分子机制,肌肉祖先的迁移和分化.
主要方法:
- 在ovo功能增益实验中通过将SDF-1结构电穿孔到VLL中进行了利用.
- 采用了使用CXCR4抑制剂珠植入VLL的功能丧失方法.
- 分析了c-Met,Pax3,MyoD和MyoR等关键发育标志物的表达.
主要成果:
- 在dermomyotome的VLL中确定了CXCR4表达,与Pax3和MyoR表达相关.
- 功能获取实验导致c-Met,Pax3和MyoD的表达增加.
- 功能丧失实验导致这些关键肌肉发育标记物的表达减少.
结论:
- CXCR4在皮肤肌瘤的VLL中得到表达.
- CXCR4 / SDF-1信号轴在调节肌肉祖先的迁移和随后的身体壁肌肉发育方面发挥着至关重要的作用.
相关概念视频
Muscles of the Thorax
1.8K
The thorax muscles are central to the body's respiration and provide essential support and movement for the upper body. They are intricately designed to facilitate the complex breathing process while also contributing to the structural integrity and mobility of the chest and upper limbs.
The diaphragm is at the core of thoracic musculature, the primary muscle involved in breathing. This expansive, dome-shaped muscle marks the division between the thoracic and abdominal cavities. It...
The diaphragm is at the core of thoracic musculature, the primary muscle involved in breathing. This expansive, dome-shaped muscle marks the division between the thoracic and abdominal cavities. It...
1.8K
Development of the Sexual Organs in the Embryo and Fetus
756
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
756
Axial and Appendicular Muscles
1.4K
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
1.4K
Formation of Muscle Fibers from Myoblasts
4.9K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.9K
Development of the Lymphatic System
734
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
734
The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K


