长长的上升性自身脊髓神经元是异质的,并且会受到脊髓损伤诱导的解剖塑性
Brandon L Brown1, Neha Anil2, Gregory States3
1Interdisciplinary Program in Translational Neuroscience, University of Louisville, Louisville, KY, United States; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States; Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, United States.
Experimental neurology
|December 9, 2023
概括
长上升的自身脊髓神经元 (LAPNs) 在脊髓损伤 (SCI) 后经历了显著的解剖变化. 这些LAPN的可塑性变化可能导致受伤后肢体协调发生变化.
科学领域:
- 神经科学是一个神经科学.
- 脊髓损伤研究 脊髓损伤研究
- 发动机控制器的控制器
背景情况:
- 长长的上升性脊髓神经元 (LAPN) 连接遥远的脊髓段.
- 在脊髓损伤 (SCI) 之前和之后,LAPN对于肢体间协调至关重要.
- 以前的研究表明,LAPN沉默会破坏四肢协调,但令人惊的是,SCI后改善了运动.
研究的目的:
- 为了解剖学地描述LAPN及其在SCI之后的可塑性.
- 为了研究轻度胸部伤SCI后LAPNs的形态变化.
- 了解LAPN的解剖变化如何与SCI后的功能恢复和协调有关.
主要方法:
- 详细的解剖特征的LAPNs. 详细的解剖特征.
- 在动物模型中诱导轻度胸部伤性SCI.
- 分析LAPN形态,包括体大小,神经元复杂性和方向,SCI前后.
- 在不同脊髓区域的附带密度的量化.
主要成果:
- 基于形态学的三个不同的LAPN子集的识别.
- 在SCI后的两个LAPN子集中观察到神经元方向向dorsoventral方向的转变.
- 宫扩张的附带密度降低和尾部到损伤中心的密度增加.
- 在SCI后,LAPN沉默改善了后肢协调,与受伤前的影响不同.
结论:
- 在LAPN中,SCI诱导了显著的解剖性可塑性,包括改变神经元的方向和附带分布.
- 这些SCI后LAPN的解剖变化可能代表了不适应性可塑性.
- 这种可塑性可能是试图整合发芽的感官附带体并保持脊髓平衡的尝试.
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