B组还是不是B组? 在重大创伤患者中,ABO,早期死亡率和器官功能障碍之间存在关联,这些患者患有冲击
Henry Schofield1, Charlotte Lindsay1, Karim Brohi1
1Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, London, United Kingdom; Barts Health National Health Service Trust, London, United Kingdom.
Journal of thrombosis and haemostasis : JTH
|December 9, 2023
概括
在创伤患者中,ABO血型B患者的早期死亡率较低,但并发症风险增加. 这表明B组的血液静止能力增强,影响严重受伤后的生存结果.
科学领域:
- 创伤和紧急医疗医学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- ABO血型影响凝血和创伤的结果.
- 创伤诱导的凝血病,休克和ABO组的存活率之间的联系尚不清楚.
研究的目的:
- 调查 ABO 组与严重出血创伤中的凝血概况,死亡率和免疫并发症的关联.
- 为了描述ABO组对创伤患者的结果的差异.
主要方法:
- 在英国主要创伤中心对严重受伤的成年创伤患者的观察队列研究.
- 对临床和实验室变量的分析,包括冲击子组中的凝血生物标志物和旋转血栓凝结仪.
- 单变量和多变量分析以评估ABO组之间的临床结果和差异.
主要成果:
- 在119名创伤患者中,ABO组之间没有整体死亡率差异.
- 在休克患者中,B组的24小时死亡率显著降低 (7%vs.16%),但侵入性通风和置换疗法的比率更高.
- 冲击的B组患者表现出更高的纤维素素水平,VIII因子,XIX因子,XIII因子和·维勒布兰德因子.
结论:
- 患有ABO血型B的创伤患者表现出增强的静血能力,与改善早期休克生存有关.
- 尽管有生存益处,但ABO组B与免疫介导并发症的风险增加有关.
- 需要进一步的研究,考虑到单个时间点抽样和子组分析的局限性.
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