瓶壁对冷干燥速度的影响
Matjaž Ramšak1, Matjaž Hriberšek1
1Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, Maribor SI-2000, Slovenia.
Journal of pharmaceutical sciences
|December 9, 2023
概括
较厚的瓶壁显著增加了冷干燥时间. 使用具有不同导热性的材料,如聚合物或瓶,也会影响干燥速度,为冷干燥过程提供潜在的优化.
科学领域:
- 制药科学 制药科学
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 冷干燥 (溶解) 是稳定药品的关键过程.
- 众所周知,瓶子的特性,如壁厚和导热率,会影响冷干燥的效率.
- 优化冷干燥周期对于减少加工时间和成本至关重要.
研究的目的:
- 通过使用数值模拟来研究瓶壁导热率和厚度对冷干燥速度的影响.
- 分析瓶壁内的热传递作为一个独特的计算领域.
- 通过实验数据验证数值模型.
主要方法:
- 使用边界元素方法进行了曼尼托尔冷干燥的2D轴对称数值模拟.
- 瓶壁中的热传递被纳入作为一个额外的计算领域.
- 该模型使用内部和文献实验数据进行了验证.
主要成果:
- 将玻璃瓶厚度从1毫米增加到2毫米显著增加了初级干燥时间,将重力度传热系数 (Kv) 提高了高达20%.
- 与玻璃瓶相比,聚合物瓶的KV降低了5.6% (在50mTorr) 和12.2% (在400mTorr),相比之下,玻璃瓶的KV降低了5.6% (在50mTorr).
- 瓶的KV增加较小,为3.7% (低压) 和2.3% (高压).
结论:
- 瓶壁厚度是冷干燥中主要干燥时间的主要决定因素.
- 瓶子的材料选择,考虑到导热性,可以调节冷干燥动力学.
- 数值方法为优化瓶子设计和冷干燥过程参数提供了有价值的工具.
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