基于聚乙烯醇/奇托桑的快速溶解微针用于局部口服麻醉
Quanpeng Li1, Xueqing Yu1, Xiaoyan Zheng1
1Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, Shaanxi, China.
新的微针可以提供快速的口服麻醉,克服注射疼痛和奶油不适. 这种创新方法为牙科手术提供了更快,更有效的疼痛缓解.
科学领域:
- 生物材料科学 生物材料科学
- 牙科麻醉 牙科麻醉
- 药物输送系统 药物输送系统
背景情况:
- 目前用于口腔局部麻醉的临床方法,包括直接注射和局部药膏,存在重大挑战.
- 这些挑战包括患者的疼痛,恐惧,不适以及口腔的潮湿环境,这些都会降低麻醉疗效.
- 需要改进有效和患者友好的口服麻醉方法.
研究的目的:
- 设计和评估一种用于口腔局部麻醉的新型利多卡因加载聚烯利/聚乙醇 (PVP/PVA) 可溶性微针 (DMNP) 系统.
- 评估开发的微针的快速释放,粘附,机械性能,麻醉疗效和生物相容性.
主要方法:
- 使用PVP/PVA尖端制造微针,以快速溶解药物,并使用PVA/Chitosan支持粘附.
- 将利多卡因化物 (Lido) 纳入具有高药物载荷能力的微针结构.
- 使用机械性质测试,体外药物释放研究和Von Frey测试评估微针性能,以比较麻醉的开始和持续时间与局部奶油.
主要成果:
- 利多-PVP/PVA DMNP微针在5分钟内显示出快速溶解和药物释放,从而达到麻醉.
- 该PVA/Chitosan支持提供了良好的粘附性口腔粘膜,抵抗唾液侵蚀和提高药物利用.
- 微针显示了明显更快的麻醉发作 (5分钟) 与局部奶油 (30分钟) 相比,具有良好的机械性能插入和高药物负载 (3mg/MN).
结论:
- 开发的Lido-PVP/PVA DMNP微针为口腔局部麻醉提供了一个有前途的替代方案.
- 这种新型的微针系统提供了快速,有效和患者友好的麻醉,克服了当前方法的局限性.
- 该系统具有出色的生物相容性和粘附性,表明在口腔中临床应用的巨大潜力.
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