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智能伤口包裹可同时在现场检测和消除致病细菌

Jianmin Yang¹, Yuxiang He², Zhendong Li²

¹College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China; Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China; International Joint Laboratory of Intelligent Health Care, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China.

Acta biomaterialia

|December 9, 2023

概括

智能伤口带通过光和光动力疗法检测和消除细菌. 这种新的方法与智能手机应用程序相结合,可以快速诊断和治疗伤口感染,有助于愈合.

科学领域:

生物材料科学生物材料科学
医学诊断医学诊断医学诊断
传染病管理传染病管理

背景情况:

伤口感染阻碍了愈合,并造成严重的健康风险.
早期发现和治疗病原体对于有效的伤口管理至关重要.

研究的目的:

开发一种智能伤口包裹,同时在现场检测和消除致病细菌.
为创建一个点的护理诊断工具与治疗能力的伤口感染集成.

主要方法:

一种可注射的水凝敷料由碳甲基和氧化氨酸酸盐组成.
嵌入的4-甲基贝利费龙β-D-糖化物 (MUG) 用于通过光进行视觉细菌检测,以及用二氧化 (UCNPs@TiO2) 涂覆的上转化纳米颗粒用于光动力学治疗.
开发了一个基于智能手机的系统,配备了一个Android应用程序,用于快速检测病原体 (到10^3 CFU).

主要成果:

包裹可以通过MUG诱导的蓝色光对细菌进行视觉检测.
在近红外辐射下,UCNPs@TiO2通过产生反应性氧物种表现出强大的抗菌活性.
该系统在老鼠伤口模型中实现了快速的现场病原体检测和有效的细菌消除,显示出有利于愈合的效果.

结论:

智能伤口带为早期诊断和按需治疗伤口感染提供了一个有前途的解决方案.
这项技术促进了及时干预,改善了伤口管理结果.
综合系统增强了在早期管理传染病原体的潜力.

关键词:

抗菌光动力学疗法是一种抗菌疗法.在现场检测检测.智能伤口包裹智能伤口包裹远程护理服务提供者伤口感染伤口感染

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