室内颗粒物度和空气清洁剂干预与COPD前吸烟者的生物标志物相关
Ashraf Fawzy1, Han Woo1, Sarath Raju1
1Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA.
室内空气污染,特别是超细颗粒 (PM<0.1),与COPD患者的炎症增加,血小板激活和氧化应激有关. 空气清洁剂的干预措施并没有显著降低这些生物标志物.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 生物标志物研究 生物标志物研究
背景情况:
- 室内空气污染物与慢性阻塞性肺病 (COPD) 的不良结果有关.
- 虽然环境污染的影响已知,但室内污染对COPD生物标志物的影响仍然不清楚.
研究的目的:
- 研究室内颗粒物 (PM) 与COPD前吸烟者的各种生物标志物之间的关联.
- 评估便携式空气净化器干预措施在减少这些生物标志物的有效性.
主要方法:
- 随机对照试验涉及COPD的前吸烟者.
- 室内PM (PM2.5,PM10,超细颗粒[UFP;PM<0.1]) 和炎症,血小板激活,内皮功能障碍和氧化应激的生物标志物的纵向测量.
- 分析使用多变量线性混合模型和空气净化器干预的处理意图.
主要成果:
- 更细微的PM分量,特别是UFP,与炎症 (IL-8,干扰素-γ) 和氧化应激生物标志物 (TBARS,8-异质) 的增加有关.
- UFP和PM2.5与较高的血小板激活标志物 (11dTxB2,P-selectin,CD40L) 相相关.
- 在PM和内皮功能障碍生物标志物之间没有发现显著的关联,空气清洁剂干预也没有降低生物标志物水平.
结论:
- 室内空气污染物,特别是UFP,与COPD患者的炎症,血小板激活和氧化应激生物标志物增加有关.
- 一种便携式空气净化器的干预并没有显著改变这些与污染相关的生物标志物水平.
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