开发和验证一种简短的查工具,用于检测非处方可代因成
Jacqui McCoy1, Suzanne Nielsen2, Raimondo Bruno1
1University of Tasmania, Churchill Ave, Hobart, TAS, 7005, Australia.
Research in social & administrative pharmacy : RSAP
|December 9, 2023
概括
一个新的四项可代因依赖度表 (CDS) 可以帮助社区药房识别有可代因依赖风险的个人. 这个简短的工具有助于对潜在的阿片类药物使用障碍进行早期干预.
科学领域:
- 药理学和药房实践中的药理学和药房实践
- 成 药物 药物 药物 药物
- 心理测量 心理测量 心理测量
背景情况:
- 在几个国家,低剂量的代代因可以在非处方药店获得,这引发了对滥用的担忧.
- 识别有代因依赖风险的个体对于预防不良结果至关重要.
研究的目的:
- 开发和验证一个简洁的选工具来评估代因依赖风险.
- 该工具旨在在社区药房设置中实践实施.
主要方法:
- 为了发展和验证尺度,进行了两项研究.
- 项目生成涉及分析频繁使用可代因的心理社会和药学变量 (N=795).
- 使用了确认因素分析 (CFA) 和接收器操作特征 (ROC) 分析,使用依赖程度尺度和DSM-5阿片类药物使用障碍 (OUD) 标准 (AUDADIS-IV) 进行验证.
主要成果:
- 四项可代因依赖度表 (CDS) 的切断值为≥2,对DSM-5可代因相关的OUD显示了76%的敏感性和48%的特异性.
- 从长度来看,CDS在15个月后的基线实现了对15个月后的可代因相关OUD病例的正确分类率为72%.
结论:
- CDS提供了合理的灵敏度来识别可代因依赖风险,尽管具体性受到其简短性的限制.
- 其非对抗性项目为非处方可代因使用者在社区药房提供药剂师主导的简短干预 (SBI).
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