变化的口腔微生物群和免疫功能障碍在中国老年精神分裂症患者:一个横截面研究
Zongxin Ling1,2, Yiwen Cheng3,4, Xia Liu5
1Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China. lingzongxin@zju.edu.cn.
Translational psychiatry
|December 9, 2023
概括
研究人员在老年精神分裂症患者中发现了明显的口腔细菌特征,这表明口腔微生物群可能是诊断和治疗的生物标志物.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 精神分裂症 (SZ) 是一种复杂的神经发育障碍,原因不明.
- 肠道微生物群在SZ中的作用是公认的,但口腔微生物群的联系还没有得到充分研究.
- 口腔微生物群可能为SZ病原发生提供新的见解.
研究的目的:
- 为了研究老年精神分裂症患者的舌头涂层微生物群和炎症概况.
- 为了确定精神分裂症的潜在口腔微生物生物标志物.
- 探索口腔失生症和SZ免疫变化的关系.
主要方法:
- 分析了118名老年精神分裂症患者和97名健康对照.
- 使用Illumina MiSeq测序进行了舌头涂层微生物群分析.
- 多重免疫试验评估了炎症概况.
主要成果:
- 精神分裂症患者表现出口腔微生物群中的α-多样性减少和β-多样性改变.
- 鉴定出明显的口腔失生症,Streptococcus/Fusobacterium增加和Prevotella/Veillonella减少.
- 观察到改变的微生物群功能,特别是在脂质和氨基酸代谢中.
结论:
- 口腔微生物群的变化,包括特定的细菌属,与老年人的精神分裂症有关.
- 链球菌/Prevotella的比率可能表明SZ.口腔失生症在SZ.
- 这些发现为老年人精神分裂症的诊断和治疗提供了潜在的新目标.
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