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Updated: Jul 8, 2025

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利用 PROTAC 技术对抗压力激素受体激活

Mahshid Gazorpak1,2, Karina M Hugentobler3, Dominique Paul4

  • 1Laboratory of Epigenetics and Neuroendocrinology, Institute for Neuroscience, Department of Health Science and Technology, ETH Zürich, 8057, Zürich, Switzerland.

Nature communications
|December 9, 2023
PubMed
概括

一种新型的向蛋白质溶解的嵌合体,KH-103,在没有遗传修饰的情况下有效地消耗葡萄糖皮质体受体 (GR). 这种选择性GR降解剂为与压力相关的疾病和研究应用提供了一个有前途的治疗策略.

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