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相关实验视频

Updated: Jul 8, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
11:42

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

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对于固相合成的总洗消除.

Jonathan M Collins1, Sandeep K Singh2, Travis A White2

  • 1Peptide Synthesis Research, CEM Corporation, 3100 Smith Farm Rd, Matthews, NC, 28104, USA. jon.collins@cem.com.

Nature communications
|December 9, 2023
PubMed
概括
此摘要是机器生成的。

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一种新的固相合成 (SPPS) 方法消除了溶剂密集型洗步骤. 这一突破显著减少了浪费,并加快了的生产速度,而不会影响质量.

科学领域:

  • 化学工程是化学工程的重要组成部分.
  • 有机化学 有机化学
  • 生物技术是生物技术.

背景情况:

  • 固相合成 (SPPS) 是生产的基石.
  • 传统的SPPS涉及多个溶剂密集型洗步骤,导致大量的浪费和更长的处理时间.

研究的目的:

  • 开发一种新的SPPS工艺,可以消除溶剂密集型洗步骤.
  • 提高制造的效率,速度和可持续性.

主要方法:

  • 引入了一种用于SPPS的工艺,该工艺通过散装蒸发去除挥发性Fmoc脱保护基.
  • 使用定向头空气冲洗来防止蒸发过程中的凝结.
  • 在研究和生产尺度上演示了这个过程.

主要成果:

  • 在氨基酸添加循环中完全消除了溶剂密集的洗步骤.
  • 实现了大量的废物减少 (高达95%) 并将基数使用量减少到标准数量的10-15%.
  • 保持了产品质量,可以挑战长达89个氨基酸的序列.
  • 从研究到生产水平的可扩展性.

结论:

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相关实验视频

Last Updated: Jul 8, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

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An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
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  • 这种新的SPPS工艺为制造效率提供了变革性的改进.
  • 该方法是快速的,高纯度的,可扩展的和高度可持续的.
  • 这一进步可能会扩大对基于的治疗方法的获取.