在肝硬化患者中评估与肉类相关的危险因素:一个病例对照研究
LeYao Xiao1,2, Mei Dai1,2, Fei Zhao1,2
1Deparment of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
Scientific reports
|December 9, 2023
概括
标志着肌肉损失和肌肉衰弱的萨尔科佩尼亚,影响了超过四分之一的肝硬化患者. 诸如年龄,体力活动和营养状况等因素影响其发育,运动可能会改善结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 肌肉质量和强度下降的萨尔科佩尼亚在肝硬化患者中很普遍,与预后不佳和死亡率相关.
- 由于诊断标准和人群的差异,有关肝硬化中的流行病学数据有限且不一致.
- 这项研究解决了需要更清楚地了解萨科佩尼亚的患病率和肝硬化影响因素的需求.
研究的目的:
- 为了确定在肝硬化患者中 Sarcopenia 的流行率.
- 在这个人群中识别与肉症相关的因素.
- 探索潜在的干预措施来管理肝硬化中的.
主要方法:
- 一项涉及271名肝硬化患者的横截面研究.
- 根据亚洲萨尔科佩尼亚工作组 (AWGS 2019) 标准 (肌肉质量,力量/身体表现) 进行的萨尔科佩尼亚诊断.
- 二元物流回归分析以确定影响因素.
主要成果:
- 萨科佩尼亚的患病率总体为27.7% (男性为27.3%,女性为28.4%).
- 发现与年龄,体力活动,BMI,中上臂肌圈,肝脑病,营养状况,性酸酶,白蛋白和总胆固醇有显著的相关性.
- 经过调整后,年龄的相关性减弱,但肉症仍然与年龄,体力活动,BMI,营养状况和白蛋白独立相关.
结论:
- 在肝硬化患者中,肉类是常见的.
- 年龄,体力活动,BMI,营养状况和白蛋白是与肉类相关的独立因素.
- 血清性酸酶和总胆固醇水平与肉症的发展有关;定期炼可能有利于握力和肝功能.
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