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Updated: Jul 10, 2026

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辐射诱导肠道损伤的动态细胞微环境的单细胞地图

Hao Lu1, Hua Yan1, Xiaoyu Li1

  • 1Beijing Institute of Radiation Medicine, Beijing, 100850, China.

Communications biology
|December 9, 2023
PubMed
概括

这项研究揭示了放射治疗后肠道的动态变化,详细说明了不同细胞如何反应和相互作用. 它在辐射诱导的肠损伤和再生期间绘制复杂的细胞环境.

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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...