周围免疫和发生性脑疾病的风险:对161,968名参与者的前性队列研究
Xiaoling Zhong1,2, Yixuan Qiang3, Ling Wang2
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Translational psychiatry
|December 9, 2023
概括
外围先天性免疫标记物,如中性粒细胞,与患痴呆症和严重抑郁症 (MDD) 等脑部疾病的风险增加有关. 这表明神经炎症对大脑健康和疾病发展起着作用.
科学领域:
- 神经免疫学 神经免疫学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 周围免疫和长期大脑健康之间的关系尚未完全理解.
- 调查外围免疫标记可能为神经和精神疾病的发展提供见解.
研究的目的:
- 检查周围免疫标记物与各种脑部疾病发生率之间的纵向关联.
- 探索将外周免疫与大脑结构改变联系起来的潜在机制.
主要方法:
- 利用了来自161,968名参与者的英国生物库数据,随访时间中位数为9.66年.
- 采用Cox的比例危险模型和受限制的立方脊柱模型来评估免疫标记物 (白细胞,比率,CRP) 与大脑疾病风险.
- 用线性回归用于神经成像分析,以将免疫标记与大脑结构变化相关联.
主要成果:
- 增加的先天性免疫标志物 (中性粒细胞,单细胞,血小板,NLR,SII) 与更高的脑部疾病风险有关.
- 中性粒细胞与痴呆症,中风,严重抑郁症 (MDD) 和焦虑症的关联最强.
- 神经成像揭示了外围免疫标记物与与痴呆和精神疾病相关的区域中的结构性大脑变化之间的联系.
结论:
- 周围的先天免疫力,特别是中性粒细胞水平,有望与患痴呆症,中风,MDD和焦虑症的风险增加有关.
- 研究结果支持神经炎症在各种脑部疾病的病因学中的作用.
- 这些见解可能为新的治疗策略铺平了道路,针对对大脑健康的外周免疫力.
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