精神兴奋剂药物对脑儿童身体功能的影响:范围审查
Anwar B Almutairi1, Naif Z Alrashdi2, Laura Vogtle3
1Department of Physical Therapy, Faculty of Allied Health, Kuwait University, Jabriya, Kuwait. almutairi.anwar@ku.edu.kw.
Pediatric research
|December 9, 2023
概括
像莫达菲尼尔这样的中枢神经系统 (CNS) 兴奋剂在改善脑 (CP) 儿童的身体功能方面显示出有限,低质量的证据. 需要更多的研究来证实对性和步态的影响.
科学领域:
- 儿科神经学 儿科神经学
- 康复医学 康复医学 康复医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 大脑 (CP) 是一组影响运动和姿势的疾病,通常会影响身体功能.
- 中枢神经系统 (CNS) 兴奋剂药物有时被认为是神经疾病,但它们在CP中的作用尚未明确.
- 了解中枢神经系统刺激剂对CP儿童身体功能的影响,对于治疗开发至关重要.
研究的目的:
- 对中枢神经系统刺激药物对CP儿童身体功能影响的文献进行范围审查.
- 评估该主题可用的研究范围和深度.
- 确定特定的中枢神经系统刺激剂及其对儿科CP的身体功能结果所报告的影响.
主要方法:
- 从2002年1月到2022年8月,对主要数据库 (PubMed,CINAHL,Cochrane,SPORTDiscus,Embase,Scopus) 进行系统的文献搜索.
- 纳入标准侧重于研究中枢神经系统刺激剂对被诊断患有CP的儿童身体功能的影响.
- 分析了四项选定的同行评审研究,所有研究莫达菲尼尔.
主要成果:
- 在包括的四项研究中,有三项报告了modafinil对CP儿童的性,运动性能和步态产生积极影响.
- 一项研究发现,莫达菲尼尔对评估的身体功能结果没有显著影响.
- 关于modafinil对儿科CP的身体功能影响的总体证据质量被确定为非常低.
结论:
- 目前的证据表明,莫达菲尼尔可能会带来一些身体益处,包括减少性和改善CP儿童的步态参数,但这基于非常有限和不一致的数据.
- 关于儿童脑中对身体功能的中枢神经系统刺激剂的现有研究是稀疏和不确定的.
- 需要进一步进行高质量的研究,以确定中枢神经系统兴奋剂对治疗CP儿童身体功能缺陷的有效性和安全性.
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