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证实了中部早期青春期女孩血清25OHD水平较低及其严重程度之间的关联

Liya Xu¹, Pin Li², Dandan Yuan¹

¹Department of Pediatric Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.

|December 9, 2023

概括

维生素D水平通常在患有中部早期青春期 (CPP) 的女孩中较低,无论疾病的进展速度如何. 像BMI和IGF-1这样的因素,而不是维生素D,影响了快速的CPP进展,而季节影响了维生素D状态.

科学领域:

儿科内分泌学儿科内分泌学
营养科学营养科学
生殖健康生殖健康

背景情况:

中央早期青春期 (CPP) 涉及儿童早期的性发育.
评估CPP女孩的维生素D状况对于了解潜在的健康影响至关重要.
区分快速渐进 (RP) 和缓慢渐进 (SP) CPP可能会揭示不同的潜在因素.

研究的目的:

为了比较RP-CPP和SP-CPP的女孩之间的维生素D水平.
确定影响CPP女孩维生素D状况的因素.
确定特定因素是否与CPP的进展率相关.

主要方法:

一项涉及340名被诊断患有CPP的女孩的横截面研究.
分析了基线数据,性腺激素释放激素 (GnRH) 刺激试验和血清25-基维生素D (25OHD) 水平.
统计分析以比较群体并确定风险因素,考虑到季节性变化.

主要成果:

大多数女孩 (97.1%) 的维生素D水平不足或不足 (平均25OHD:15.89 ng/mL).
在RP-CPP和SP-CPP组之间没有发现25OHD水平的显著差异.
较高的BMI,IGF-1水平和峰值LH/FSH比率是RP-CPP的独立风险因素,而季节与25OHD水平显著相关.

结论:

维生素D缺乏/不足在患有CPP的女孩中很普遍,但与疾病进展类型无关.
诸如BMI,IGF-1和荷尔蒙比率等因素,而不是维生素D水平,驱动RP-CPP.
季节性变化是这种人群中维生素D状况的主要决定因素.

关键词:

25-基维生素D (25OHD) 是一种25-基维生素.中部早期青春期 (CPP)维生素D缺乏症是因为缺乏维生素D.

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