不同的COVID-19疫苗在2-[18F]FDG-PET/CT中的系统性影响
Tina Nazerani-Zemann1, Birgit Pernthaler2, Gerold Schwantzer3
1Division of Nuclear Medicine, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9A, 8038, Graz, Austria. tina.nazerani-zemann@medunigraz.at.
Scientific reports
|December 9, 2023
概括
接种COVID-19疫苗会增加2-[18F]FDG在带淋巴结中的吸收,根据疫苗类型,在接种后的不同时间达到活动峰值. 这种吸收在70天内恢复到基线,这对于解释PET/CT扫描至关重要.
科学领域:
- 核医学是一种核医学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- COVID-19疫苗接种计划使用各种疫苗,包括mRNA和病毒载体类型.
- 疫苗接种后的代谢活动发生了变化,特别是淋巴结中的2-[18F]FDG吸收.
- 了解这些变化对于准确解释PET/CT扫描至关重要,特别是在瘤病患者中.
研究的目的:
- 通过三种不同的COVID-19疫苗接种疫苗后,评估下淋巴结和其他器官的代谢活性.
- 分析疫苗接种后2-[18F]FDG吸收的时间依赖性变化.
- 为了比较不同类型疫苗的全身代谢反应.
主要方法:
- 对接受COVID-19疫苗 (BioNTech/Pfizer,Moderna,AstraZeneca) 的220名患者进行了回顾性分析.
- 2-[18F]FDG-PET/CT扫描在接种疫苗后的第1天和第135天之间进行.
- 计算和比较了状淋巴结和参考器官 (肝脏,脏,骨髓,血液池) 的SUVmax.
主要成果:
- 在接种疫苗后的双侧支淋巴结中观察到增加的2-[18F]FDG吸收,每种疫苗在不同的时间达到峰值.
- 随着时间的推移,手臂淋巴结活动通常会下降,70天后恢复到背景水平.
- 虽然淋巴结吸收因疫苗而异 (Moderna的峰值比AstraZeneca晚),但在SUVmax或对参考器官的比率方面,没有发现疫苗组之间的显著统计差异.
结论:
- 接种COVID-19疫苗会在2-[18F]FDG PET/CT上诱导下淋巴结代谢活动的短暂,可检测的变化.
- 了解疫苗类型和疫苗接种以来的时间对于准确解释PET/CT扫描至关重要.
- 这些发现有助于区分疫苗诱导的淋巴腺病与其他病理状况,特别是在瘤成像中.
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