在怀孕期间用选择性血清素再吸收抑制剂治疗母亲和延迟新生儿适应:基于人口的队列研究
Marie-Coralie Cornet1, Yvonne W Wu2,3, Heather Forquer4
1Department of Pediatrics, University of California San Francisco, San Francisco, California, USA marie-coralie.cornet@ucsf.edu.
Archives of disease in childhood. Fetal and neonatal edition
|December 10, 2023
概括
选择性血红素再吸收抑制剂 (SSRI) 在怀孕晚期使用会增加延迟新生儿适应的风险. 这种关联取决于SSRI类型和剂量,这表明存在因果关系.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 新生儿适应新生儿适应
- 药物监督 药物监督 药物监督
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 的使用在怀孕期间很普遍.
- 以前的研究表明,SSRI暴露与新生儿适应迟缓之间存在潜在联系.
- 在了解母亲心理健康严重程度,SSRI类型和剂量对新生儿结果的影响方面存在差距.
研究的目的:
- 调查怀孕后期SSRI暴露与新生儿适应延迟之间的关联.
- 要确定这种关联是否独立于母亲的抑郁和焦虑严重程度.
- 检查SSRI类型和剂量对新生儿适应的影响.
主要方法:
- 基于大量人口的出生队列 (280,090名婴儿) 的回顾性分析.
- 数据来源于电子医疗记录,包括药房,孕产妇,怀孕和新生儿信息.
- 暴露定义为在怀孕20周后开放的SSRI处方.
主要成果:
- 2.7%的婴儿在怀孕晚期暴露于SSRI.
- 暴露于SSRI的婴儿显示出延迟新生儿适应的发生率显著更高 (11.2%与4.4%相比).
- 经过多变量调整后,这种关联仍然显著,并显示出剂量依赖的关系,其中埃斯基塔洛普拉姆和弗洛克塞丁具有最高的风险.
结论:
- 在怀孕晚期暴露于SSRI的婴儿面临延迟新生儿适应的高风险.
- 观察到的SSRI暴露,类型和剂量之间的关系表明存在潜在的因果关系.
- 需要进一步的研究来阐明机制和临床影响.
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