物理和认知表现变化的时间模式
Pankaja Desai1, Shannon Halloway2, Kristin R Krueger1
1Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
概括
老年人的身体和认知能力下降通常在短时间内同时发生. 了解这些相互关联的变化对于开发及时干预措施以支持健康老龄化至关重要.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 研究了老年人群中身体和认知表现下降之间的关系.
- 专注于一大群老年人,以了解与年龄相关的变化.
研究的目的:
- 检查老年人身体和认知功能下降之间的时间关联.
- 确定身体衰退是否预测认知衰退,反之亦然,以及所涉及的时间滞后.
主要方法:
- 利用了7,483名成年人 (平均年龄72岁) 的基于人口的队列.
- 用3个标准化测试评估身体表现,用4个测试评估认知功能.
- 采用混合效应线性回归模型来分析随时间变化的变化,调整共变量.
主要成果:
- 认知功能的下降最强烈地预测了在同一3年间的身体衰退.
- 认知衰退在身体衰退后的1个时间间隔中显示出较弱的关联,后来变得无意义.
- 双向分析显示了类似的模式,表明身体和认知能力的下降往往会同时发生.
结论:
- 身体和认知功能下降似乎紧密相关,并在短时间内同时发生.
- 进一步研究驱动这些同时发生的变化的短期机制对于干预开发至关重要.
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