在患有直肠癌的患者接受全新辅助疗法后,RAS/BRAF突变与完整反应之间的关联:一项前性多中心研究
Sergei Bedrikovetski1, Luke Traeger2,3, Tracy Fitzsimmons2,3
1Colorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, SA, Australia. sergei.bedrikovetski@gmail.com.
Annals of surgical oncology
|December 10, 2023
概括
在接受全新辅助疗法 (TNT) 的晚期直肠癌患者中,RAS/BRAF突变显著降低了完全响应率. 野生型RAS/BRAF状态与更好的治疗结果有关,这表明有针对性的治疗选择的潜力.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
背景情况:
- RAS/BRAF突变在直肠癌治疗反应中的作用尚不清楚.
- 总的新辅助疗法 (TNT) 越来越多地用于晚期直肠癌.
- 预测治疗反应对于优化患者治疗结果至关重要.
研究的目的:
- 评估RAS/BRAF突变对晚期直肠癌中TNT反应率的影响.
- 为了比较突变RAS/BRAF (mutRAS) 和野生型RAS/BRAF (wtRAS) 的患者之间的完整反应率.
主要方法:
- 对80名用TNT治疗的晚期直肠癌患者进行前性观察性研究.
- 根据分子测试,将患者分为mutRAS和wtRAS组.
- 评估整体完整响应 (oCR) 率,包括临床完整响应 (cCR) 和病理完整响应 (pCR).
主要成果:
- 与wtRAS患者相比,mutRAS患者 (53.8%) 的cCR (14%对37.8%) 和oCR (11.6%对43.2%) 率显著降低.
- 两组之间没有观察到pCR率的显著差异.
- 转移性疾病应答率在mutRAS和wtRAS组之间没有显著差异.
结论:
- 在晚期直肠癌中,RAS/BRAF突变与初级瘤对TNT反应较差有关.
- 需要进一步的大规模研究来探索RAS/BRAF状态,以指导直肠癌的治疗选择.
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