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原始硫衍生可持续硫的抗炎和抗氧化活性量子点

Ruchir Priyadarshi^1,2, Hyunjin Choi^1,3, Hail Kim^1,3

¹BioNanocomposite Research Center, Kyung Hee University, Seoul, Republic of Korea.

Journal of biomedical materials research. Part A

|December 10, 2023

概括

乙二胺被动硫量子点 (ED-SQD) 显示出显著的抗氧化和抗炎作用. 这些无毒的纳米材料显示出生物医学应用的前景,特别是在管理炎症条件.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

硫量子点 (SQD) 是新兴的纳米材料,具有多种生物医学特性.
乙二胺被动化增强了生物应用的SQD特性.
炎症和氧化应激是治疗干预的关键目标.

研究的目的:

合成和表征乙二胺被动硫量子点 (ED-SQDs).
评估ED-SQDs的细胞毒性,抗氧化和抗炎潜力.
探索ED-SQD在巨细胞中的作用的潜在分子机制.

主要方法:

ED-SQDs 的水热合成.
使用RAW264.7细胞进行体外细胞毒性测定.
自由基清除试验 (ABTS, DPPH) 进行.
在LPS刺激的巨细胞中评估炎症标记物 (氧化,细胞因子) 和信号通路 (STAT3,NRF2).

主要成果:

在ED-SQD中,细胞毒性较低,细胞活力高 (>90%在500μg/mL),IC50为880.9μg/mL.
观察到强烈的体外抗氧化活性,与 Askorbic 酸相当.
ED-SQDs通过降低氧化,活性氧物种和促炎细胞因子,有效地降低了巨细胞的炎症反应,同时调节了STAT3和NRF2通路.

结论:

在无毒度下,ED-SQD具有显著的抗氧化和抗炎性质.
这些发现支持ED-SQDs作为炎症疾病治疗剂的潜力.
对ED-SQD的进一步研究可能会导致新的纳米医学策略.

关键词:

具有抗炎作用的抗炎作用.抗氧化剂活性抗氧化剂活性生物医学应用程序乙烯基胺是一种硫的量子点是一个量子点.

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