营养素的风险评估:必须有一个对其影响的值
Michiel Rh Löwik1, Arne Astrup2, Alan R Boobis3
1Tzitzo, Veenendaal, 3904 DM, the Netherlands.
Regulatory toxicology and pharmacology : RTP
|December 10, 2023
概括
欧洲食品安全局 (EFSA) 关于添加糖的指南值得怀疑. 糖的不良影响显示了一个值,表明需要更多的数据来确定饮食糖的安全上限摄入水平.
科学领域:
- 营养科学 营养科学
- 风险评估 风险评估
- 公共卫生 营养 公共卫生 营养
背景情况:
- 营养效应取决于剂量,这是一个在风险评估中经常被忽视的关键因素.
- 最近的欧洲食品安全局 (EFSA) 2022年关于添加糖和自由糖的结论建议摄入.
- 尽可能低,
- 可能误解剂量反应关系.
研究的目的:
- 批判性地评估EFSA2022年关于添加糖和自由糖摄入量的结论.
- 为了确定是否存在糖消费不利影响的门值.
- 评估当前数据是否足以确定糖类的可容忍上限摄入量水平.
主要方法:
- 分析EFSA引用的随机对照试验 (RCT),重点关注像禁食葡萄糖和甘油三等替代终点.
- 检查来自RCT的剂量反应数据,以确定潜在的值效应.
- 审查关于糖摄入量和不良健康结果的现有科学文献.
主要成果:
- 欧洲食品安全局使用的RCT显示,在摄入量低至10%的能量水平时,对禁食葡萄糖或甘油三没有不良影响.
- 这表明,糖对这些特定终点的不利影响存在可观察到的值.
- 审查的数据表明,缺乏确定的证据来确定饮食糖的可容忍上限摄入水平.
结论:
- 为了尽量减少添加糖的摄入量,EFSA的结论可能无法完全得到提交的证据的支持,因为值效应很明显.
- 目前的数据不足以确定添加糖的最终上限.
- 需要更强大的研究来准确确定糖摄入不良影响的门.
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