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Updated: Jul 8, 2025

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Published on: January 20, 2019

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白血病的表观遗传脆弱性含有失活的EZH2突变

Mona A Alqazzaz1, Genna M Luciani2, Victoria Vu1

  • 1Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto, Ontario, Canada.

Experimental hematology
|December 10, 2023
PubMed
概括

突变EZH2在AML和MDS/MPN等血液癌症中悖论地增加了对EZH2抑制剂的敏感性,触发了细胞死亡途径. 这一发现提供了关于表观遗传脆弱性和疾病病因学的见解.

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