在COVID-19治疗的系统性审查中,研究元素的临床和方法影响往往是无结构的和不充分报告的:a metaresearch study study
Waldemar Siemens1, Gina Bantle2, Sonja Mahler2
1Institute for Evidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany.
Journal of clinical epidemiology
|December 10, 2023
概括
大多数COVID-19治疗系统性审查 (SRs) 包括研究影响 (IfRs),但PICO元素是无结构的,GRADE概念很少被报告. 需要进一步努力,在SR中标准化IFR报告.
科学领域:
- 医学研究 医学研究
- 证据综合 证据综合
- 临床试验设计 临床试验设计
背景情况:
- 由于COVID-19临床试验的快速发展,需要在系统性审查 (SR) 中对研究 (IfRs) 进行信息化影响.
- 系统审查和元分析 (PRISMA) 2020年首选报告项目清单包括IfRs.
- 柯克伦手册建议使用人口,干预,控制,结果 (PICO) 和建议评级,评估,开发和评估 (GRADE) 领域来告知IFR.
研究的目的:
- 评估COVID-19治疗的SR中IFR陈述的存在.
- 检查这些SR中的IfR语句的信息元素,特别是PICO和GRADE概念.
主要方法:
- 一项超级研究研究分析了来自Living OVerview of the Evidence数据库的COVID-19治疗方法的SR.
- 如果R语句被定义为包含规划未来研究信息的句子.
- 数据提取侧重于PICO元素,研究设计和GRADE概念,由三位作者独立提取.
主要成果:
- 在326个SR中,284个 (87.1%) 包括IFR.
- 解决PICO的IfR语句是非结构化的,通常报告人口,干预和结果,但很少控制.
- 在IfR中很少报告GRADE概念 (例如偏差风险4.9%,不准确2.8%).
结论:
- 近90%的COVID-19治疗SRs包括IfRs,但报告没有结构.
- 使用PICO元素是常见的,而GRADE概念很少被整合到IfRs中.
- 建议对未来的SR进行IFR报告的标准化,考虑PICO和GRADE.
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