来自宿主和动物传染病原体的EF手蛋白的功能
Wei Zuo1, Mingxing Tian1, Jingjing Qi1
1Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Microbes and infection
|December 10, 2023
概括
EF手蛋白调节生物过程,影响宿主免疫和动物感染. 本综述详细介绍了它们的结构, (Ca2+) 亲和力,目标和机制,帮助未来的研究策略.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- EF手蛋白是各种生物过程的关键调节者.
- 它们在宿主免疫和病原体相互作用中的作用越来越被认可.
研究的目的:
- 综合审查EF手蛋白在宿主-病原体相互作用中的功能.
- 阐明EF手蛋白在免疫和感染中的结构和功能机制.
- 讨论关于EF手蛋白特征定义较少的研究.
主要方法:
- 文献综述和对EF手蛋白现有研究的综合.
- 分析结构数据, (Ca2+) 结合亲缘关系和下游目标.
- 在宿主和动物感染病原体的背景下检查功能机制.
主要成果:
- EF手蛋白具有多样化的结构和 (Ca2+) 结合特性.
- 这些蛋白调节宿主免疫反应,并影响病原体的生存和毒性.
- 在各种病原体中确定了特定的下游目标和功能途径.
结论:
- EF手蛋白是宿主免疫和感染动态中的关键参与者.
- 了解它们的详细机制对于开发新的治疗策略至关重要.
- 审查提供了一个框架,以谨慎和有效的未来研究在这个领域.
更多相关视频
08:40Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
59.0K
07:53A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
Published on: January 9, 2019
33.2K
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Receptor-mediated Endocytosis
104.6K
Overview
104.6K
Mechanism of Filopodia Formation
2.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.3K
Adherens Junctions
4.8K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
4.8K
Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
Mechanical Protein Functions
4.9K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
4.9K
