Rab11通过调节EGFR和EpCAM外分体分泌来抑制头癌
Kunihiro Yoshida1, Kaung Htike2, Takanori Eguchi3
1Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan.
Rab11蛋白通过调节受体循环和外体细胞分泌来抑制头平分细胞癌 (HNSCC) 的进展. Rab11b 是 HNSCC 患者的一个有前途的预后标志物.
科学领域:
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
- 分子生物学分子生物学
背景情况:
- Rab11蛋白 (Rab11a和Rab11b) 是细胞内贩运的关键调节者,参与受体循环和外体分泌.
- 虽然Rab11在癌症进展中的作用已知,但其在头角状细胞癌 (HNSCC) 中的特定功能在很大程度上仍未被描述.
研究的目的:
- 调查Rab11a和Rab11b在HNSCC中的作用.
- 确定HNSCC患者Rab11表达的临床意义.
主要方法:
- 利用公共数据库分析和组织微阵列来评估HNSCC中的Rab11表达.
- 生成稳定的HNSCC细胞系与改变的Rab11a或Rab11b表达 (损失和收益) 来研究细胞功能.
- 评估了对增殖,迁移,入侵,表皮生长因子受体 (EGFR) 循环和外体细胞分泌的影响.
主要成果:
- 在HNSCC.中,Rab11b mRNA表达与有利的患者存活率相关.
- 随着HNSCC阶段的进展,Rab11b的表达减少了.
- 过度表达Rab11a/Rab11b降低了EGFR,EpCAM外体分泌,迁移和入侵.
- 击败Rab11a/Rab11b增加了EpCAM/CD9外体的分泌,迁移和入侵.
结论:
- Rab11通过调节EGFR循环和EpCAM外分体分泌来抑制HNSCC的进展.
- Rab11b是HNSCC的一个重要预后指标.
- Rab11蛋白代表了HNSCC.的潜在治疗点.
更多相关视频
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
相关概念视频
Mitogens and the Cell Cycle
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
Abnormal Proliferation
Regulation of Angiogenesis and Blood Supply
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
