益生菌和胰岛素的协生组合可以通过调节肠道微生物群来改善NAFLD
Can Zhang1, Tianqi Fang2, Linlin Shi1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
协生菌是一种益生菌和益生菌的组合,通过改善脂质代谢和肠道健康,有效治疗非酒精性脂肪性肝病 (NAFLD). 这项研究表明,酸奶中的协生菌调节肠道微生物群,为NAFLD预防提供了一种新的治疗方法.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 肠道微生物群失生症与非酒精性脂肪性肝病 (NAFLD) 的发生有关.
- 协生菌,结合益生菌和益生菌,是肠道微生物群的强大调节剂.
- 探索协生菌作为NAFLD的治疗策略是有必要的.
研究的目的:
- 研究协生菌 (益生菌:Streptococcus Bifidobacterium和Streptococcus thermophilus;益生菌:胰岛素) 作为早期NAFLD治疗干预的疗效.
- 评估通过酸奶输送的协生菌对NAFLD小鼠模型中代谢参数和肠道健康的影响.
主要方法:
- 一种协生菌配方 (益生菌 + 胰岛素) 被添加到酸奶中,并给患有饮食引起的NAFLD的小鼠.
- 生物化学指标 (总胆固醇,甘油三,LDL-C,HDL-C,胰岛素抵抗) 被评估.
- 分析了AMPK和NFκB信号通路,肠道屏障功能和肠道微生物群组成 (16SrRNA测序).
主要成果:
- 协生酸奶 (HS) 显著改善了NAFLD小鼠的脂质概况和胰岛素耐药性 (P<.01).
- HS治疗激活了AMPK和NFκB信号通路,增强了脂质代谢,减少了炎症.
- HS恢复了肠道屏障的完整性和调节了肠道微生物群,特别是减少了Firmicutes/Bacteroidetes比率 (P< .01).
结论:
- 通过酸奶输送的共生菌在预防和治疗与肥胖相关的NAFLD方面显示出显著的治疗潜力.
- 该机制涉及调节肠肝轴,改善脂质代谢,并产生抗炎和抗氧化作用.
- 这些发现为开发基于协生菌的NAFLD预防策略提供了强有力的理论基础.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.


