在使用不同算法识别的成年人中,第四阶段CKD的发病率和预后的变化:基于人口的队列研究
Mitchell Rath1, Pietro Ravani2, Matthew T James2
1Alberta Health Services, Provincial Research and Data Services, University of Calgary, Calgary, Alberta, Canada.
概括
定义慢性病 (CKD) 阶段G4的更严格的标准减少了发病率估计,并确定了病结果更差的患者. 这些发现影响了疾病负担计算和对CKD管理的临床决策.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 临床指南定义慢性病 (CKD) 使用超过3个月的持续时间标准.
- 这个持续时间标准的实施可能会有所不同,影响疾病发病率和流行率的估计.
- 对于CKD G4阶段 (eGFR 15-29mL/min/1.73m2) 的特定定义,对于科转诊至关重要,已不一致地应用.
研究的目的:
- 研究不同算法对CKD G4阶段的发病率和预后的影响.
- 为了比较基于四个不同的基于eGFR的算法来定义CKD G4队列的结果.
- 通过强调所选定义的影响,为临床报告和研究提供信息.
主要方法:
- 一项基于人口的队列研究在加拿大阿尔伯塔省进行,使用行政和实验室数据.
- 在2015年4月至2018年3月期间,在成年人中发现了发生的CKD G4阶段病例 (eGFR 15-29mL/min/1.73m2).
- 用四种越来越严格的算法来定义CKD G4队列:单个测试,两个测试,放松持续和严格持续.
主要成果:
- 随着更严格的算法,CKD G4的发病率显著下降,从每10万人/年中的190.7个降至79.9个.
- 由持续的eGFR减少定义的队列显示了可比的大小和1年事件概率.
- 一次测试和两次测试的队列较大,并且具有更高的eGFR改善概率.
结论:
- 对于CKD G4定义的更严格的算法导致更低的发病率估计.
- 严格的定义确定了一个患者群体,其eGFR改善的概率较低,功能衰竭的风险更高.
- 算法选择显著影响CKD G4负担估计,个体预后和临床决策.
关键词:
行政数据 管理数据G4 G4 G4 G4 的意思是什么?算法算法是一种算法.慢性脏疾病 慢性脏疾病定义的定义定义的定义.流行病学流行病学球膜过率是指球膜的过率发生率的发生率.功能衰竭 功能衰竭是什么?死亡率 死亡率预后 预后 预后严重的CKD严重的CKD.第四阶段的CKD更多相关视频
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