风险的静脉血栓塞栓症和心脏代谢障碍的后代从血栓易发的血脉血统的后代

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Bengt Zöller¹, Jan Sundquist¹, Kristina Sundquist¹

¹Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden.

Journal of thrombosis and haemostasis : JTH

|December 10, 2023

概括

来自静脉血栓塞栓症 (VTE) 发病率高的家庭的儿童面临着风险增加的VTE和相关心脏代谢条件. 这项研究强调了扩大家族病史在评估血栓形成风险方面的重要性.

科学领域:

遗传学和流行病学
心血管医学心血管医学
血栓形成研究研究

背景情况:

关于静脉血栓栓塞 (VTE) 的传统家庭研究主要检查一级亲属.
扩大家族病史在VTE和心脏代谢障碍风险中的作用仍未得到充分研究.

研究的目的:

调查扩大血统中的VTE密度与后代VTE和心脏代谢疾病风险之间的关联.
使用基于血统的方法来评估VTE和相关条件的家族聚合.

主要方法:

分析了482,185个瑞典血统,包括751,060个核心后代的扩大家庭成员 (父母,阿/叔叔,祖父母,表亲).
根据VTE密度将血统分为8个经验级别.
评估VTE和心脏代谢障碍的后代风险与血统VTE密度相关,并应用Bonferroni校正.

主要成果:

血统中高密度的VTE显著增加了后代患各种VTE表现的风险 (DVT,PE,与怀孕有关的VTE,异常血栓,表面血栓炎) 和血栓友.
血统VTE密度增加与第一个VTE事件的年龄较小和子女患肥胖,糖尿病,痛风,静脉缩和动脉栓塞/血栓形成的风险较高有关.
对于其他几种心血管和代谢疾病,包括高血压,冠心病和中风,没有发现显著的关联.

结论:

具有高VTE密度的血统后代对VTE和特定心脏代谢疾病的风险显著增加.
扩大家族病史,特别是VTE密度,是识别患有这些疾病风险较高的人的关键因素.

关键词:

心脏代谢的危险因素心血管疾病心血管疾病流行病学流行病学家庭历史家庭历史静脉血栓塞栓症是一种静脉血栓塞栓.

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