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Updated: Jul 8, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

[成人B细胞急性淋巴细胞白血病的CAR-T疗法]

¹Department of Hematology, Hokkaido University Hospital.

[Rinsho ketsueki] The Japanese journal of clinical hematology

|December 10, 2023

概括

化学抗原受体T细胞 (CAR-T) 疗法对B细胞急性淋巴细胞白血病 (B-ALL) 的成年人有希望,该病已经复发或是耐火性. 本综述涵盖了在这个具有挑战性的患者群体中CAR-T治疗的最新证据.

科学领域:

血液学血液学血液学
免疫治疗是一种免疫疗法.
在瘤学瘤学.

背景情况:

成年B细胞急性淋巴细胞白血病 (B-ALL) 经常复发或对初始治疗变得耐药.
包括新药和干细胞移植在内的标准疗法在复发/耐药B-ALL的长期存活率有限.
针对CD19的CAR-T疗法为B-ALL提供了一个有前途的治疗途径.

结论:

卡特-T疗法在治疗复发性/耐药性成人B-ALL方面取得了重大进展.
在成年人中扩大CAR-T治疗的获取和有效性是一个至关重要的未满足的需求.
对CAR-T疗法的持续研究对于改善成年B-ALL患者的治疗结果至关重要.

关键词:

B-ALL,所有的人.在CART-T中,我们可以使用CAR-T.化学抗原受体的化学抗原受体在白血病中,白血病.

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