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[恶性淋巴瘤的CAR-T疗法]
1Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious.
[Rinsho ketsueki] The Japanese journal of clinical hematology
|December 10, 2023
概括
化学抗原受体T细胞 (CAR-T) 治疗为复发或耐火性B细胞非霍奇金淋巴瘤提供了新的希望. 已批准的CD19 CAR-T疗法在扩散性大B细胞淋巴瘤和卵泡淋巴瘤患者中显示出显著的响应率和长期缓解.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- B细胞非霍奇金淋巴瘤,包括扩散性大B细胞淋巴瘤 (DLBCL) 和卵泡淋巴瘤 (FL),是一种异构的恶性瘤.
- 复发性或耐药性疾病 (R/R) 是一个重大挑战,预后不佳.
- 化学抗原受体T细胞 (CAR-T) 疗法代表了管理R/R B细胞淋巴瘤的范式转变.
结论:
- CAR-T疗法正在改变R/R DLBCL和FL的治疗环境.
- 现实世界的数据支持在临床试验中观察到的疗效.
- 了解疗效和毒性对于患者管理和未来的治疗开发至关重要.
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