药理和非药理干预措施,以预防心脏手术后妄想:一个系统审查和元分析的协议
Elizabeth Cottuli de Cothi1, Rachel Perry1, Rahul Kota1
1University of Bristol, Bristol, UK.
BMJ open
|December 10, 2023
概括
本系统性审查确定了预防心脏手术后常见并发症妄的干预措施. 目标是找到有效的策略来减少妄想发病率并改善患者的治疗结果.
科学领域:
- 医学研究 医学研究
- 临床干预措施 临床干预
- 系统审查是系统的审查.
背景情况:
- 痴呆症是一种注意力和认知障碍综合征,影响到50%的心脏手术后的患者.
- 这种并发症与较高的死亡率,延长住院时间和长期认知障碍有关.
研究的目的:
- 系统地审查随机对照试验,评估心脏手术后妄预防的干预措施.
- 确定有效的药理和非药理策略,以减轻术后妄想.
主要方法:
- 在多个电子数据库和试验登记册中对相关的随机对照试验进行全面搜索.
- 由两名审稿人进行独立选和数据提取;使用Cochrane RoB2工具进行偏差风险评估.
- 研究结果的叙述综合和元分析 (如果可能的话),遵守PRISMA指南.
主要成果:
- 主要结局:妄想的发生率.
- 二级结局:妄想持续时间,死亡率,住院/ICU,神经复杂症,生活质量和不良事件.
- 结果将通过叙事审查和潜在的元分析进行综合.
结论:
- 心脏手术后术后痴呆症的有效预防措施至关重要.
- 这一系统性审查将提供指导临床实践的证据,并减少妄想的负担.
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