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解读LPS/TLR4通路,神经递质和deltamethrin诱导的抑郁类行为之间的相互作用:从肠-大脑轴的角度看

Tongtong Li¹, Hao Chen¹, Baohua Xu¹

¹Department of Applied Biology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.

Pesticide biochemistry and physiology

|December 10, 2023

概括

德尔塔美 (DM) 暴露会通过破坏肠-大脑轴来引起抑郁行为. 这种杀虫剂暴露会损害肠道屏障和大脑,改变肠道细菌和神经递质,导致神经毒性.

科学领域:

环境毒理学环境毒理学
神经科学是一个神经科学.
微生物学微生物学

背景情况:

德尔塔米特林 (DM) 的不当使用导致其在各种环境矩阵和人体中积累.
暴露于DM与神经毒性和行为异常有关,但机制尚不清楚.
肠-大脑轴越来越多地被认为在中枢神经系统 (CNS) 疾病中的作用.

研究的目的:

为了研究肠-大脑轴在小鼠德尔塔美林诱导的行为异常中的作用.
阐明DM诱导的神经毒性和行为变化的潜在机制.

主要方法:

小鼠被暴露在德尔塔美林中.
进行行为测试以评估类似抑郁的行为.
分析了海马和肠道组织的结构完整性和蛋白质表达.
用16S rRNA测序分析了肠道微生物组成.
进行了便微生物群移植 (FMT).

主要成果:

暴露于DM诱发了类似抑郁的行为,并破坏了海马结构.
观察到肠道屏障完整性受损,脂多糖 (LPS) 泄漏增加.
接触DM改变了神经递质通路,特别是抑制了5-基三胺 (5-HT) 的产生.
发生了肠道微生物群失调,特定的细菌与行为和生理变化相关.
FMT实验表明,DM诱导的肠道失调会导致类似抑郁的行为.

结论:

德尔塔美林诱导的神经毒性和行为变化显着由微生物群-肠-大脑轴介导.
肠道屏障的破坏,炎症和肠道微生物群组成的改变是关键机制.
准肠道微生物群可能为deltamethrin毒性提供一种新的治疗策略.

关键词:

德尔塔米特林是一种类似抑郁症的行为我们的肠道微生物群.肠-大脑轴肠-大脑轴神经递质神经递质

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