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Updated: Jul 8, 2025

Imaging Dpp Release from a Drosophila Wing Disc

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Published on: October 30, 2019

通过DPP介导的TGF-β信号,通过20-hydroxyecdysone信号来调节白菜甲虫的生育

Kou Wang¹, Wen Liu¹, Xiao-Ping Wang¹

¹Hubei Key Laboratory of Resources Utilization and Sustainable Pest Management, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Pesticide biochemistry and physiology

|December 10, 2023

概括

Dpp信号通路通过影响生来调节雌性昆虫的繁殖. 这一途径影响20-基乙 (20E) 受体表达和营养利用,提供害虫控制目标.

科学领域:

昆虫的生殖生物学昆虫的生殖生物学
分子信号通道的分子信号通道.
发育生物学是发展生物学.

背景情况:

改变增长因子-β (TGF-β) 超级家族的信号传递,特别是Decapentaplegic (Dpp) 信号传递,对于昆虫的发育至关重要.
Dpp信号在雌性昆虫繁殖中的确切作用,特别是在生 (黄蛋白合成) 期间,尚未完全理解.

研究的目的:

为了研究DPP信号在卵巢发育和昆虫Colaphellus bowringi中的生过程中的作用.
阐明DPP信号影响女性生殖的分子机制,包括其与其他关键途径的相互作用.

主要方法:

在生殖发育过程中对DPP信号组件的基因表达概况.
RNA干扰 (RNAi) 破坏了关键的DPP信号基因 (Dpp,Punt,Mad,Medea,Tkv) 和20-基素受体 (EcR).
评估卵巢发育,生和生理参数 (干重,蛋白质含量,mTOR表达).

主要成果:

在C. bowringi. 卵巢发育期间,DPP信号基因被上调.
对Dpp,Tkv,Mad和Medea基因的破坏显著损害了卵巢发育和细胞生成.
发现DPP信号影响了20-基乙 (20E) 受体 (EcR) 和其响应基因在脂肪体中的表达.
EcR的淘汰模仿了在DPP通路基因淘汰中观察到的表型,这表明DPP通过EcR传递信号的调节作用.
干扰DPP或ECR信号减少了成年雌性干重,蛋白质含量和mTOR表达,这表明对营养利用的影响.

结论:

Dpp信号通路是雌性昆虫中生和卵巢发育的关键调节者.
通过影响20E通路和脂肪体中营养利用 (AA/TOR介导) 来调节Dpp信号,从而调节生命生成.
这项研究为昆虫繁殖网络提供了新的见解,并确定了旨在破坏雌性繁殖的害虫控制策略的潜在目标.

关键词:

在 Dpp 中,dpp 是指 Dpp.这就是为什么EcrR EcR.生殖生殖生殖生殖繁殖在TGF-β的基础上.维特洛基尼斯的产生

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