牛血清album-fucoidan纳米复合物中黄素和黄素的同时封装,采用两步pH驱动的方法
Xiao Chen1, Hao Qin1, Jia-Ming Zhai1
1Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, China.
Journal of the science of food and agriculture
|December 10, 2023
概括
这项研究开发了牛血清阿尔伯明-富科伊丹纳米颗粒,以增强黄素和青素的生物可用性. 混合纳米颗粒显示pH值依赖的形成和封装化合物的差异释放.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物化学 生物化学
背景情况:
- 黄素 (CUR) 和黄素 (ACN) 具有有益的生物活性,但口服生物可用性较差.
- 开发有效的输送系统对于提高这些化合物的营养价值和健康益处至关重要.
- 聚糖蛋白复合纳米颗粒为改善生物活性物质的生物可用性提供了一个有希望的策略.
研究的目的:
- 制造牛血清白蛋白 (BSA) - 富可伊丹 (FUC) 混合纳米颗粒,用于共同输送CUR和ACN.
- 为了研究pH驱动的制造方法,并描述由此产生的纳米复合体.
- 评估从BSA-FUC纳米颗粒中CUR和ACN的封装效率和释放动力学.
主要方法:
- 采用两步pH驱动的方法来合成BSA-FUC混合纳米粒子.
- 分析了零电荷点和纳米复合体的pH依赖形成.
- 在不同的NaCl度下确定了CUR和ACN的封装效率和释放概况.
主要成果:
- BSA-FUC纳米复合物形成是pH依赖的,在特定的pH值下观察到最佳特征.
- 颗粒大小随着NaCl度的增加而增加,而CUR封装效率没有受到影响.
- 观察到不同的释放动力学:超过80%的ACN在10小时内释放,而CUR扩散的不到25%,符合Logistic和Weibull模型.
结论:
- 通过pH驱动的方法制造的BSA-FUC纳米复合材料对水友性 (ACN) 和疏水性 (CUR) 营养品的联合交付有效.
- 开发的纳米颗粒显示出改善难溶性生物活性化合物的生物可用性和治疗疗效的潜力.
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