序列交叉连接的纤维素用于快速和强化静血
Lisha Yu1,2, Zhaodi Liu1,2,3,4,5,6, Zongrui Tong1,2
1Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 10, 2023
概括
一种新的顺序交联纤维素粘合剂 (SCFG) 迅速为出血的组织形成强大,持久的密封. 这种创新的静血粘合剂提供了卓越的性能和生物相容性,以改善外科手术结果.
科学领域:
- 生物材料科学 生物材料科学
- 手术创新 在外科创新.
- 血液静止研究 血液静止研究
背景情况:
- 有效的血液静止对于手术成功和患者康复至关重要.
- 开发具有快速作用,强粘合,耐用性和生物相容性的静血粘合剂仍然是一个重大挑战.
- 控制出血需要先进的材料,能够在潮湿的外科环境中有效运行.
研究的目的:
- 开发一种新的顺序交联纤维素粘合剂 (SCFG),用于有效控制出血.
- 评估SCFG在凝时间,粘合强度,耐用性和生物相容性方面的性能.
- 为了比较SCFG与现有的静血剂和材料的疗效.
主要方法:
- 制造一个连续交联纤维素粘合剂 (SCFG) 与两个不同的交联网络.
- 在几秒钟内在现场形成第一个纤维素网络,以实现初始屏障功能.
- 凝甲烯基基前体的结合和交叉连接,形成一个强大的第二网络,增强粘附性和耐用性.
- 评估机械性能,包括破裂压力,剪切强度和湿组织的界面性.
- 在老鼠,子和猪出血模型中体内评估SCFG的疗效和安全性.
主要成果:
- SCFG在2秒内展示了超快速的现场凝.
- 开发的粘合剂表现出高爆压 (≈280 mmHg) 和强大的剪切强度 (38 kPa).
- SCFG用湿组织 (约60 J m−2的界面性) 创建了坚固的接口,优于商业代理商.
- 在体内研究证实,SCFG是多种动物模型中血液组织的有效和安全密封剂.
- 该材料显示出出色的生物相容性和易于制造.
结论:
- 序列交叉连接纤维素 (SCFG) 为在手术期间挑战血静提供了一个有希望的解决方案.
- SCFG的快速作用,强大的粘合力和耐久性比目前的静血方法提供了显著的优势.
- 生物相容性和易于制造的SCFG支持其在治疗出血方面广泛临床应用的潜力.
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