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索马托斯坦素影响GnRH神经元的发育和迁移,并刺激与嗅觉相关的纤维结

Shizuko Murakami¹, Hiroko Ohki-Hamazaki², Yasuo Uchiyama¹

¹Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Developmental neurobiology

|December 10, 2023

概括

索马托斯坦素 (SST) 在胚胎中暂时表达,有助于淋巴激素释放激素 (GnRH) 神经元的发育和迁移. SST促进了GnRH神经元的神经发生,迁移和嗅觉纤维粘结.

科学领域:

发育神经科学的发展神经科学.
神经内分泌学神经内分泌学

背景情况:

过渡性体静止素 (SST) 表达发生在胚胎的嗅觉上皮质 (OE) 和神经中.
SST表达与性腺激素释放激素 (GnRH) 神经元从OE迁移到前脑 (FB) 的迁移一致.

研究的目的:

调查SST在GnRH神经元发育和迁移中的作用.
确定SST对与嗅觉相关的神经元发育和纤维纤维化的影响.

主要方法:

在卵子中对小干扰RNA (siRNA) 进行电解,以抑制小的嗅觉斑点 (OP) 中的SST mRNA.
对GnRH和Islet-1免疫反应神经元,细胞亡,增殖和HuC/D阳性细胞的分析.
用SST,八二或SST抗体治疗的整体OP探索培养物;评估GnRH神经元迁移和纤维结.

主要成果:

SST抑制减少了鼻腔区域的GnRH和Islet-1神经元,但没有影响GnRH神经元进入FB.
SST敲击并没有改变细胞亡,增殖或HuC/D阳性神经元细胞数量.
SST/八胺治疗增加了迁移性GnRH神经元和距离,增强了纤维纤维化,SST抗剂阻断了效果.

结论:

SST在GnRH和其他OP衍生的迁移神经元的神经发生和分化中起着至关重要的作用.
SST促进了GnRH神经元迁移和与嗅觉相关的纤维结.
SST对GnRH和Islet-1表达神经元的发展产生促进作用.

关键词:

在GnRH神经元中.神经元迁移的神经元迁移嗅觉的位置是什么?与嗅觉相关的纤维.siRNA 是一个RNA.索马托斯塔丁是什么? 索马托斯塔丁是什么

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