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对[¹⁸F]FAPI-42 PET/CT在各种癌症中的两个时间点进行比较分析

Xingyu Mu¹, Biyun Mo¹, Jie Qin¹

¹Department of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, No. 15 Lequn Road, Xiufeng District, Guilin, 541001, Guangxi Zhuang Autonomous Region, China.

European journal of hybrid imaging

|December 10, 2023

概括

早期[18F]FAPI-42 PET/CT显示高病变检测和吸收,胆汁保留减少. 这表明早期成像是优化[18F]FAPI-42 PET/CT协议的可行策略.

科学领域:

核医学就是核医学.
放射化学放射化学是指辐射化学.
瘤成像学成像学

背景情况:

纤维细胞激活蛋白 (FAP) 是一种跨膜蛋白酶,涉及瘤层.
[18F]FAPI标记剂在瘤学中提供了有前途的诊断潜力.
优化成像协议可以提高诊断准确度.

研究的目的:

评估[18F]FAPI-42在早期和晚期的生物分布,检测率和病变吸收率.
为了比较早期[18F]FAPI-42 PET/CT与2-[18F]FDG PET/CT的性能.
为了确定[18F]FAPI-42 PET/CT协议的早期获取的可行性.

主要方法:

对60名接受[18F]FAPI-42 PET/CT 早期和晚期间隔的患者进行前性研究.
在病变和正常器官中标记剂吸收的视觉和半定量分析.
在11名患者中,小组分析比较早期的[18F]FAPI-42 PET/CT与2-[18F]FDG PET/CT.

主要成果:

与晚期成像相比,早期[18F]FAPI-42 PET/CT 显示出更高的病变检测率和视觉得分.
在早期图像中,损伤的吸收率显著更高,在晚期图像中吸收率下降 (p < 0.05).
早期的[18F]FAPI-42 PET/CT与2-[18F]FDG PET/CT相比,显示出更好的检测和吸收.

结论:

早期[18F]FAPI-42 PET/CT提供了一致的病变检测和吸收.
与晚期成像相比,早期成像减少了胆道系统中的标记物保留.
早期获取是优化[18F]FAPI-42 PET/CT协议的一个可行的策略.

关键词:

2-[18F]FDGG 这是一个很好的方法.聚乙烯/聚乙烯/聚乙烯两个时间点.[18F]FAPI-42 的使用方法

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